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Protein kinase A (PKA) is an important intracellular substance that regulates substance metabolism and biological functions, which exerts a wide range of biological effects through phosphorylation of specific serine/threonine residues in specific proteins. PKA plays an important role in the cAMP signaling pathway, and is involved in various life activities of parasites. Therefore, investigating the role of PKA in the life activities of parasites may provide insights into the development of novel anti-parasitic targets. The review mainly describes the structure and function of PKA and its role in life activities of parasites.
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Objective@#To compare the effect on the flow conditions of adhesives and the retention force of restorations among different cement-retained methods of implant-supported fixed prostheses.@*Methods@#Four common cement-retained methods were selected, including the occlusal hole for screw access (OH), the lingual hole for adhesives overflow (LH), the resin replica for titanium abutment (RR), and the traditional cement-retained method (the control group). The adhesive used in this study was resin-modified glass ionomer cement. The two-dimensional analysis models of computational fluid dynamics (CFD) were established. The flow conditions of adhesives in the adhesion process was analyzed by the CFD analysis. The internal filling ratio and the amount of neck overflow of adhesives below the edge of the prosthesis were calculated. Ten zirconia prostheses in each group were processed and cemented. The retention force was examined by mechanical tensile experiments in vitro.@*Results@#The CFD analysis showed the internal filling ratio of adhesives from high to low was the LH group, the OH group, the RR group and the control group. The amount of neck overflow of adhesives below the edge of the prosthesis from less to more was the RR group, the OH group, the LH group and the control group. The retention force was (240.7±33.9) N in the control group, (278.2±59.1) N in the OH group, (292.9±47.9) N in the LH group, and (262.8±59.4) N in the RR group. There was a statistically significant difference in the retention force between the LH group and the control group (P=0.029). There was no significant difference among the other groups (P>0.05).@*Conclusions@#The modified cement-retained methods can effectively reduce the amount of neck overflow of adhesives, and improve the filling condition of adhesive in the adhesive clearance to ensure the retention force of the prostheses. Clinically, the appropriate modified cement-retained method should be selected according to the three-dimensional position of the implant and the position of prosthetic margin.
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Objective To investigate the effect of Yinzhihuang auxiliary light clinical effect of the treatment of neonatal jaundice, and analyze the treatment process right humanized nursing service measures. Methods 1100 children with jaundice from October 2015 to October 2016 were selected and randomly divided into the study group (n=550) and the control group (n=550). The control group with jaundice in conventional treatment combined with blue light irradiation, the study group jaundice in the control group treated with Yinzhihuang oral liquid. The clinical efficacy of two groups of jaundice children was recorded, and the data were analyzed by statistical test (SPSS). Results The total effective rate of clinical treatment in children with jaundice in the study group (94.91%) was significantly better than that in the control group the total effective rate of clinical treatment was 70.36% (P<0.05). Conclusion In the blue light plus can rise to the ideal effect of adjuvant therapy of neonatal jaundice with Yinzhihuang oral liquid, can improve the patients clinical curative effect, combined with humanized nursing service or the prognosis and quality of life of children with strong support.
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Objective To investigate the effect of Yinzhihuang auxiliary light clinical effect of the treatment of neonatal jaundice, and analyze the treatment process right humanized nursing service measures. Methods 1100 children with jaundice from October 2015 to October 2016 were selected and randomly divided into the study group (n=550) and the control group (n=550). The control group with jaundice in conventional treatment combined with blue light irradiation, the study group jaundice in the control group treated with Yinzhihuang oral liquid. The clinical efficacy of two groups of jaundice children was recorded, and the data were analyzed by statistical test (SPSS). Results The total effective rate of clinical treatment in children with jaundice in the study group (94.91%) was significantly better than that in the control group the total effective rate of clinical treatment was 70.36% (P<0.05). Conclusion In the blue light plus can rise to the ideal effect of adjuvant therapy of neonatal jaundice with Yinzhihuang oral liquid, can improve the patients clinical curative effect, combined with humanized nursing service or the prognosis and quality of life of children with strong support.
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<p><b>OBJECTIVE</b>To evaluate the association between metabolism of arsenic and DNA oxidative damage in workers in a arsenic mill.</p><p><b>METHODS</b>Urinary organic arsenic and 8-hydroxydeoxyguanine were detected in 37 workers highly exposed to arsenic and 16 administrative and logistic staff with mild exposure in a arsenic mill in Yunnan province, and also 28 local people who did not have the exposure in the near past time. The correlation between metabolism of arsenic and DNA oxidative damage was evaluated.</p><p><b>RESULTS</b>The urinary organic arsenic concentration was respectively (0.48 +/- 0.37) mg/L and (0.08 +/- 0.05) mg/L for men with high and low exposure, and was respectively 0.11 mg/L and (0.30 +/- 0.24) mg/ L for women with high and low exposure, while it was lower than 0.02 mg/L in the controls. Urinary 8-hydroxydeoxyguanine concentration was (18.07 +/- 11.68) micromol/mol creatinine, (11.79 +/- 8.25) micromol/mol creatinine, (10.07 +/- 3.04) micromol/mol creatinine for the males with high and low exposure and of controls, respectively, (P < 0.05), and it was 84.35 micromol/mol creatinine, (21.27 +/- 5.89) micromol/mol creatinine, (14.43 +/- 2.58) micromol/mol creatinine for females with high and low exposure and of controls, respectively. The female workers exposed to arsenic had higher urinary 8-hydroxydeoxyguanine levels than males did (P < 0.05). The increased tendencies of urinary 8-hydroxydeoxyguanine levels with the organic arsenic concentration were found in workers (r(s) = 0.279, P = 0.019).</p><p><b>CONCLUSION</b>Occupational individuals exposed to arsenic have obvious DNA oxidative damage, which is more severe in females. The difference of metabolism of arsenic may play a key role.</p>